DESIGN AND CHARACTERIZATION OF METOPROLOL SUCCINATE RAPIMELTS USING CO-PROCESSED SUPERDISINTEGRANTS

G.Jeevan Reddy^1*, Prashant SVS Vamaraju ²

1, 2. Sri Siddhartha Pharmacy College, Ammavarithota, Nuzvid, Krishna District, Andhra Pradesh, India – 521201

Corresponding Author:  G.Jeevan Reddy, Department of Phamaceutics, Sri Siddhartha Pharmacy College, Ammavarithota, Nuzvid, Krishna District, Andhra Pradesh, India – 521201, Email:gurralaj@mail.gvsu.edu.

Citation: G.Jeevan Reddy (2026). Design and Characterization of Metoprolol Succinate Rapimelts Using Co-Processed Superdisintegrants Eco Science Journal.2026 3(3).

Copyrights ©  2026, G.Jeevan Reddy. This article is licensed under the Creative Common Attribution-NonCommercial-4.0-international-License-(CCBY-NC).

Abstract: Metoprolol succinate belongs to the class of selective β-1-adrenoreceptor blocking agent and is widely used for the treatment of hypertension, angina pectoris and heart failure. The purpose of the present work was designed to enhance the oral bioavilability of the drug metoprolol succinate by formulating it into rapimelts by using super disintegrants of both natural super disintegrants such as FGP (Fenugreek seed powder) & IHP (Ispaghul husk powder) and synthetic super disintegrants such as SSG (Sodium starch glycolate) & CCS (Croscarmellose sodium). by its combination.

Keywords:  Metoprolol succinate, β-1-adrenoreceptor, oral bioavailability, Fenugreek, super disintegrants, hypertension.